Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
| Autor: | Sérgio Paulo Bydlowski, Juliana Sampaio-Silva, Debora Levy, Leonardo Rokita-Rosa, Fábio Alessandro de Freitas, Cadiele Oliana Reichert, Priscila de Lima Barros |
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| Rok vydání: | 2020 |
| Předmět: |
Review
medicine.disease_cause GPX4 lcsh:Chemistry Lipid peroxidation chemistry.chemical_compound Arachidonate 15-Lipoxygenase iron metabolism neurodegenerative diseases lcsh:QH301-705.5 Spectroscopy Neurons Arachidonic Acid Chemistry Brain Parkinson Disease General Medicine Glutathione ferroptosis Computer Science Applications Cell biology Huntington Disease cell death Fatty Acids Unsaturated Alzheimer’s disease Intracellular Huntington’s disease Programmed cell death Iron Catalysis Inorganic Chemistry Huntington's disease Alzheimer Disease GSH medicine Humans Physical and Theoretical Chemistry glutathione peroxidase 4 Molecular Biology Cell Membrane Organic Chemistry system xc− Phospholipid Hydroperoxide Glutathione Peroxidase medicine.disease Oxidative Stress lcsh:Biology (General) lcsh:QD1-999 Parkinson’s disease Lipid Peroxidation Oxidative stress Homeostasis |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 8765, p 8765 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential as a redox metal in several physiological functions. The brain is one of the organs known to be affected by iron homeostatic balance disruption. Since the 1960s, increased concentration of iron in the central nervous system has been associated with oxidative stress, oxidation of proteins and lipids, and cell death. Here, we review the main mechanisms involved in the process of ferroptosis such as lipid peroxidation, glutathione peroxidase 4 enzyme activity, and iron metabolism. Moreover, the association of ferroptosis with the pathophysiology of some neurodegenerative diseases, namely Alzheimer’s, Parkinson’s, and Huntington’s diseases, has also been addressed. |
| Databáze: | OpenAIRE |
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