The effect of propofol infusion on minimum alveolar concentration of sevoflurane for smooth tracheal intubation
| Autor: | Tsuyoshi Satsumae, Seiji Watanabe, Hiroshi Yamaguchi |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Minimum alveolar concentration
medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Tracheal intubation Laryngoscopy respiratory system Sevoflurane Surgery Anesthesiology and Pain Medicine Bolus (medicine) Anesthesia Anesthesiology medicine Intubation Propofol business medicine.drug |
| Zdroj: | Journal of Anesthesia. 16:28-33 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s540-002-8091-3 |
| Popis: | Purpose This study was conducted to determine the effect of propofol infusion on the minimum alveolar concentration necessary for smooth tracheal intubation (MACEI) of sevoflurane. Methods Sixty-nine patients, American Society of Anesthesiologists (ASA) status I, aged 30-49 years, were randomly assigned to one of three groups according to the agents used for tracheal intubation (n = 23 for each group): the SP group, in whom the intubation was attempted under sevoflurane plus propofol infusion; the S group, tracheal intubation under sevoflurane alone; and the P group, tracheal intubation under propofol infusion alone. Anesthesia was induced with propofol 2.5 mg.kg(-1) i.v. bolus. Prior to the tracheal intubation attempt, propofol infusion, 10 mg.kg(-1).h(-1), was given for 15 min in the SP and P groups, and sevoflurane equilibration was established in the SP and S groups. All tracheal intubation attempts were made 15 min after anesthetic induction. The end-tidal sevoflurane concentration at which tracheal intubation was attempted was predetermined by the up-and-down method (with 0.5% as a step size). MACEI was determined using a logistic regression test. Results The MACEI of sevoflurane was 1.73% in the SP group, and 2.99% in the S group. Laryngoscopy was not possible in the P group patients. Conclusion Propofol infusion reduced sevoflurane MACEI. This finding suggests that propofol would be an excellent adjuvant to use with sevoflurane for tracheal intubation. |
| Databáze: | OpenAIRE |
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