Synthesis and evaluation of substituted indolizidines as peptidomimetics of RGD tripeptide sequence
| Autor: | Delphine Halie, Joëlle Pérard-Viret, Sylvie Dufour, Jacques Royer |
|---|---|
| Přispěvatelé: | CiTCoM, CNRS, Université de Paris |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
0303 health sciences
Indolizidines Bicyclic molecule 010405 organic chemistry Allylglycine Peptidomimetic Stereochemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Indolizidine Tripeptide [CHIM.THER]Chemical Sciences/Medicinal Chemistry Condensation reaction 01 natural sciences Biochemistry Chemical synthesis 0104 chemical sciences 3. Good health 03 medical and health sciences chemistry.chemical_compound chemistry Drug Discovery 030304 developmental biology |
| Zdroj: | Tetrahedron Tetrahedron, Elsevier, 2009, 65 (7), pp.1402-1414. ⟨10.1016/j.tet.2008.12.015⟩ |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2008.12.015⟩ |
| Popis: | International audience; The synthesis of seven peptidomimetics of RGD is presented. The indolizidine building block was obtainedby condensation of allylglycine with dimethoxydihydrofuran followed by an intermolecular cyclization.The bicyclic ring was functionalised with a carboxylic acid and a guanidinium appendage. Theseven peptidomimetics were evaluated by cell-adhesion assays |
| Databáze: | OpenAIRE |
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