Growth factor signalling in endocrine and anti-growth factor resistant breast cancer
| Autor: | Helen E. Jones, Robert Ian Nicholson, Iain Robert Hutcheson, Julia Margaret Wendy Gee, Kathryn Mary Taylor, Stephen Edward Hiscox, Martin Gwyn Giles |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
medicine.medical_specialty Resistance development business.industry Endocrinology Diabetes and Metabolism Growth factor medicine.medical_treatment Endocrine resistance Breast Neoplasms medicine.disease ErbB Receptors Endocrinology Breast cancer Signalling Receptors Estrogen Internal medicine medicine Cancer research Humans Intercellular Signaling Peptides and Proteins Endocrine system Female Breast cancer cells business Signal Transduction |
| Zdroj: | Reviews in Endocrine and Metabolic Disorders. 8:241-253 |
| ISSN: | 1573-2606 1389-9155 |
| DOI: | 10.1007/s11154-007-9033-5 |
| Popis: | Growth factors provide powerful mitogenic and survival signals to breast cancer cells and it is therefore not surprising that they are able to subvert inhibitory responses to anti-hormonal drugs. In this review we discuss several mechanisms by which this may be achieved and expand our observations to encompass recently emerging anti-growth factor treatments. The information presented is underpinned by inhibitor studies that show the targeting of such mechanisms in advance of anti-hormone or anti-growth factor resistance development is able to substantially delay this event, thus pointing the way forward to intelligent combination therapies relevant to the future management of breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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