Decreased blood loss after cardiopulmonary bypass using heparin-coated circuit and 50% reduction of heparin dose
| Autor: | Stefan Thelin, Jan Borowiec, Jan Hultman, Hans-Erik Hansson, Lars Bagge |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.drug_class Surface Properties Blood Loss Surgical Urine Hemolysis law.invention Fibrin Fibrinogen Degradation Products Hemoglobins Bolus (medicine) Double-Blind Method law Monitoring Intraoperative Cardiopulmonary bypass Medicine Humans Blood Transfusion Myocardial infarction Coronary Artery Bypass Blood Coagulation Blood Volume Cardiopulmonary Bypass biology business.industry Heparin Platelet Count Fibrinolysis Anticoagulant Perioperative Middle Aged medicine.disease Protamine Myocardial Contraction medicine.anatomical_structure Hematocrit Anesthesia biology.protein Cardiology and Cardiovascular Medicine business Artery medicine.drug |
| Zdroj: | Scandinavian journal of thoracic and cardiovascular surgery. 26(3) |
| ISSN: | 0036-5580 |
| Popis: | In a randomized, double-blind study of patients undergoing elective coronary artery grafting, the effect of heparin-coated circuit combined with 50% reduction of systemic heparin bolus was investigated. Ten patients comprised group HC (heparin-coated) and ten group C (controls). The mean total doses of heparin were 172 IU/kg in group HC and 416 IU/kg in group C and the respective protamine doses were 0.96 and 3.96 mg/kg (both p < 0.001). Activated clotting times during cardiopulmonary bypass were significantly shorter in group HC, and both intra- and postoperative bleeding was significantly less than in group C (7.7 vs. 11.7 ml/kg, p = 0.036, and 6.9 vs. 9.7 ml/kg, p = 0.004). Hemoglobin loss via the drains was 22.5 g in group HC and 43.7 g in group C (p < 0.005). Hemolysis at the end of bypass was significantly greater in group C. Apart from one perioperative myocardial infarction in group HC the postoperative course was uneventful. Use of a heparin-coated circuit is concluded to permit complication-free reduction of heparin and protamine doses and to decrease both intra- and postoperative bleeding, which may favorably influence the outcome of coronary artery grafting. |
| Databáze: | OpenAIRE |
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