A meta-analysis of association between glutathione S-transferase gene polymorphism and osteosarcoma chemosensitivity in Chinese population

Autor: Rongcheng Xu, Wang Jiwei, Qi Yang, Jun Lan, Zhou Chongbin, Mingping Zhou, Haiya Zheng
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
medicine.medical_specialty
Funnel plot
Genotype
Pharmacogenomic Variants
Antineoplastic Agents
Bioinformatics
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Internal medicine
osteosarcoma
Antineoplastic Combined Chemotherapy Protocols
Odds Ratio
medicine
Humans
Radiology
Nuclear Medicine and imaging
glutathione S-transferase gene
Chemosensitivity
Glutathione Transferase
Polymorphism
Genetic
biology
business.industry
General Medicine
Odds ratio
Publication bias
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Confidence interval
meta-analysis
Treatment Outcome
030104 developmental biology
Glutathione S-transferase
Drug Resistance
Neoplasm
030220 oncology & carcinogenesis
Meta-analysis
biology.protein
Osteosarcoma
Gene polymorphism
business
Publication Bias
Zdroj: Journal of Cancer Research and Therapeutics, Vol 12, Iss 5, Pp 64-67 (2016)
ISSN: 1998-4138
0973-1482
Popis: Objective: In this study, a meta-analysis was performed to investigate whether there is an association between glutathione S-transferase (GST) gene polymorphism and chemosensitivity in patients with osteosarcoma. Methods: A comprehensive electronic database search was performed between January 1, 2016, and May 21, 2016. All eligible studies related to GST gene polymorphism and chemosensitivity in patients with osteosarcoma were screened and included in the current meta-analysis. The association between GSTT1, GSTM1 and osteosarcoma chemosensitivity was demonstrated by odds ratio (OR) and corresponding 95% confidence interval (CI). The publication bias was assessed by Begg's funnel plot. Results: A total of four studies with 681 osteosarcoma patients were included in the present study. The data were pooled by fixed effect model for lack of statistical heterogeneity. The results showed there was no significant association between GSTT1 OR = 1.04, 95% CI: 0.77–1.41, P > 0.05), GSTM1 (OR = 1.08, 95% CI: 0.80–1.46, P > 0.05) gene polymorphism and chemosensitivity in patients with osteosarcoma was found by pooled the published data. Begg's funnel plot indicated no significant publication bias in meta-analysis. Conclusion: Glutathione S-transferase gene polymorphism had no association with chemosensitivity in patients with osteosarcoma.
Databáze: OpenAIRE
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