Photothermal-modulated reversible volume transition of wireless hydrogels embedded with redox-responsive carbon dots
| Autor: | Sung Young Park, Hee-Sauk Jhon, Pham Thi My Phuong, Insik In |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Phase transition
Materials science Cell Survival Infrared Rays Acrylic Resins Biomedical Engineering Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Redox Neoplasms Quantum Dots Tumor Cells Cultured Humans General Materials Science Irradiation Nanocomposite Molecular Structure Temperature technology industry and agriculture Hydrogels Phototherapy Photothermal therapy equipment and supplies 021001 nanoscience & nanotechnology Fluorescence Carbon 0104 chemical sciences Self-healing hydrogels 0210 nano-technology Oxidation-Reduction |
| Zdroj: | Biomaterials Science. 7:4800-4812 |
| ISSN: | 2047-4849 2047-4830 |
| DOI: | 10.1039/c9bm00734b |
| Popis: | The reversible volume transition of redox-responsive hydrogels by near-infrared (NIR) irradiation has recently attracted significant attention as a novel therapy matrix for tracking and treating cancer via stimuli-responsive fluorescence on/off with controllable volume transition via a wireless sensing system. Herein, a NIR-induced redox-sensitive hydrogel was synthesized by blending a hydrogel with IR825-loaded carbon dots (CD) to achieve enhanced mobility of nanoparticles inside a gel network, and reversible volume phase transitions remotely controlled by a smartphone application via the induction of different redox environments. The presence of CD-IR825 in the thermosensitive poly(N-isopropylacrylamide) hydrogel network imparted fluorescence, electronic and photothermal properties to the hydrogels, which resulted in volume shrinkage behavior of the hydrogel upon exposure to NIR laser irradiation due to the redox-sensitive CDs. Under the NIR on/off cycles, the photothermal temperature, fluorescence, and porous structure were reversed after turning off the NIR laser. The hydrogel responsiveness under GSH and NIR light was studied using a wireless device based on the changes in the resistance graph on a smartphone application, generating a fast and simple method for the investigation of hydrogel properties. The in vitro cell viabilities of the MDA-MB cancer cells incubated with the composite hydrogel in the presence of external GSH exhibited a higher photothermal temperature, and the cancer cells were effectively killed after the NIR irradiation. Therefore, the NIR-induced redox-responsive nanocomposite hydrogel prepared herein has potential for use in cancer treatment and will enable the study of nanoparticle motion in hydrogel networks under multiple stimuli via a wireless device using a faster and more convenient method. |
| Databáze: | OpenAIRE |
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