0129: Pharmacological modulation of microparticle-mediated vascular response in a rat model of septic shock
| Autor: | Bruno Levy, Ferhat Meziani, Julie Boisramé-Helms, Fatiha Zobairi, Su Emmanuelle Degirmenci, Asael Berger, Xavier Delabranche |
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| Jazyk: | angličtina |
| Předmět: |
Mean arterial pressure
congenital hereditary and neonatal diseases and abnormalities Septic shock business.industry nutritional and metabolic diseases Hemodynamics Pharmacology medicine.disease Norepinephrine (medication) Sepsis Immunology medicine Microparticle skin and connective tissue diseases Cardiology and Cardiovascular Medicine business Vascular tissue Protein C medicine.drug |
| Zdroj: | Archives of Cardiovascular Diseases Supplements. :24-25 |
| ISSN: | 1878-6480 |
| DOI: | 10.1016/S1878-6480(14)71332-1 |
| Popis: | IntroductionCirculating procoagulant microparticles (MPs) take part in septic shock vascular dysfunction through pro-inflammatory and procoagulant detrimental effects. Aims were to study how circulating procoagulant MPs are involved in the vascular dysfunction of septic shock and to examine if the pharmacological modulation of MP could be beneficial.MethodsIn a first set of experiments, MPs were isolated from sham or septic rats obtained by cecal ligation and puncture, resuscitated and treated by activated protein C (aPC). Then, healthy recipients were inoculated with septic MPs and hemodynamic parameters were recorded during 4 hours. At the end of the record, blood and organs were harvested.ResultsTreating septic rats with aPC significantly reduced norepinephrine needs to reach the mean arterial pressure goal and leukocyte-derived MPs (6.2±2.1 vs 2.9±1.7nM PhtdSer, p |
| Databáze: | OpenAIRE |
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