Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections

Autor:	Felix Dewald, Susanne Detmer, Martin Pirkl, Martin Hellmich, Eva Heger, Maximilian Herrmann, Clara Lehmann, Janine Zweigner, Florian Klein
Rok vydání:	2022
Předmět:	Infectious Diseases SARS-CoV-2 Humans COVID-19 Immunology and Allergy Serologic Tests Viral Load Antibodies Viral
Zdroj:	The Journal of Infectious Diseases. 226:1721-1725
ISSN:	1537-6613 0022-1899
Popis:	To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac07ecd14c0abbde5d377d9c5dce77af https://doi.org/10.1093/infdis/jiac290 Zobrazit plný text záznamu