Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections
Autor: | Felix Dewald, Susanne Detmer, Martin Pirkl, Martin Hellmich, Eva Heger, Maximilian Herrmann, Clara Lehmann, Janine Zweigner, Florian Klein |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | The Journal of Infectious Diseases. 226:1721-1725 |
ISSN: | 1537-6613 0022-1899 |
Popis: | To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time. |
Databáze: | OpenAIRE |
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