Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves
Autor: | Michael T. Williams, Paula A. Soto, Robyn M. Amos-Kroohs, Rocío Martinez Vivot, Vanina Usach, Charles V. Vorhees, Gonzalo Piñero, Patricia Setton-Avruj |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Nervous system
Male medicine.medical_specialty Health Toxicology and Mutagenesis Central nervous system Gene Expression Transferrin receptor Motor Activity Toxicology Article MANGANESE Rats Sprague-Dawley purl.org/becyt/ford/1 [https] 03 medical and health sciences 0302 clinical medicine Internal medicine Peripheral myelin protein 22 medicine Animals Peripheral Nerves purl.org/becyt/ford/1.6 [https] 030304 developmental biology 0303 health sciences Manganese PERIPHERAL NERVOUS SYSTEM biology Chemistry IRON Age Factors DMT1 Iron Deficiencies Myelin basic protein Rats Endocrinology medicine.anatomical_structure Peripheral nervous system biology.protein Sciatic nerve MYELINATION 030217 neurology & neurosurgery |
Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
Popis: | Iron (Fe) deficiency (FeD) and manganese (Mn) overexposure (MnOE) may result in several neurological alterations in the nervous system. Iron deficiency produces unique neurological deficits due to its elemental role in central nervous system (CNS) development and myelination, which might persist after normalization of Fe in the diet. Conversely, MnOE is associated with diverse neurocognitive deficits. Despite these well-known neurotoxic effects on the CNS, the influence of FeD and MnOE on the peripheral nervous system (PNS) remains poorly understood. The aim of the present investigation was to examine the effects of developmental FeD and MnOE or their combination on the sciatic nerve of young and adult rats. The parameters measured included divalent metal transporter 1 (DMT1), transferrin receptor (TfR), myelin basic protein (MBP) and peripheral myelin protein 22 (PMP22) expression, as well as Fe levels in the nerve. Our results showed that FeD produced a significant reduction in MBP and PMP22 content at P29, which persisted at P60 after Fe-sufficient diet replenishment regardless of Mn exposure levels. At P60 MnOE significantly increased sciatic nerve Fe content and DMT1 expression. However, the combination of FeD and MnOE produced no marked motor skill impairment. Evidence indicates that FeD appears to hinder developmental peripheral myelination, while MnOE may directly alter Fe homeostasis. Further studies are required to elucidate the interplay between these pathological conditions. Fil: Amos Kroohs, Robyn M.. University of North Carolina; Estados Unidos Fil: Usach, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Piñero, Gonzalo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Vorhees, Charles V.. University of Cincinnati; Estados Unidos Fil: Martínez Vivot, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Soto, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Williams, Michael T.. University of Cincinnati; Estados Unidos Fil: Setton, Clara Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina |
Databáze: | OpenAIRE |
Externí odkaz: |