Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis
| Autor: | Declan T. Chard, Ferran Prados Carrasco, Arman Eshaghi, M Pardini, Azmain Chowdhury, James William L. Brown, Claudia Gandini Wheeler-Kingshott, Baris Kanber, Rebecca S. Samson, Steven H. P. van de Pavert, Carole H. Sudre |
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| Přispěvatelé: | Brown, James William L., Chowdhury, Azmain, Kanber, Baris, Prados Carrasco, Ferran, Eshaghi, Arman, Sudre, Carole H., Pardini, Matteo, Samson, Rebecca S., van de Pavert, Steven H.P., Gandini Wheeler-Kingshott, Claudia, Chard, Declan T. |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male secondary progressive multiple sclerosis Pathology medicine.medical_specialty magnetisation transfer ratio normal-appearing white matter Primary progressive multiple sclerosis Magnetisation transfer ratio Esclerosi múltiple magnetisation transfer ratio Primary Progressive Multiple Sclerosis Multiple sclerosis Cohort Studies 03 medical and health sciences Multiple Sclerosis Relapsing-Remitting 0302 clinical medicine Humans Medicine normal-appearing white matter 030304 developmental biology Cerebral Cortex 0303 health sciences Secondary progressive multiple sclerosis Magnetisation transfer business.industry Middle Aged Multiple Sclerosis Chronic Progressive medicine.disease Magnetic Resonance Imaging White Matter Normal-appearing white matter Neurology Esclerosis múltiple Female Neurology (clinical) Abnormality business 030217 neurology & neurosurgery |
| Zdroj: | Brown, J W L, Chowdhury, A, Kanber, B, Prados Carrasco, F, Eshaghi, A, Sudre, C H, Pardini, M, Samson, R S, van de Pavert, S H, Wheeler-Kingshott, C G & Chard, D T 2019, ' Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis ', Multiple sclerosis (Houndmills, Basingstoke, England) . https://doi.org/10.1177/1352458519841810 O2, repositorio institucional de la UOC Universitat Oberta de Catalunya (UOC) |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458519841810 |
| Popis: | Background: In relapse-onset multiple sclerosis (MS), tissue abnormality – as assessed with magnetisation transfer ratio (MTR) imaging – is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes. |
| Databáze: | OpenAIRE |
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