The overriding role of surgery and tumor grade for long‐term survival in patients with gastroenteropancreatic neuroendocrine neoplasms: A population‐based cohort study
| Autor: | Einar Gudlaugsson, Oddvar Sandvik, Jan Terje Kvaløy, Jon Arne Søreide, Mohammed S. S. Al-Saiddi, Torjan M. Haslerud, Dordi Lea, Lars Normann Karlsen, Herish Garresori, Kjetil Søreide |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male gastrointestinal neuroendocrine tumors Cancer Research medicine.medical_specialty Adolescent kreft Population Disease outcomes survival surgery Tumor grade GEP-NEN Stomach Neoplasms GEP‐NEN medicine Humans Stage (cooking) education Child kirurgi RC254-282 Aged Aged 80 and over education.field_of_study WHO grading business.industry Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 [VDP] Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged Prognosis Survival Analysis Appendix Surgery Pancreatic Neoplasms Neuroendocrine Tumors medicine.anatomical_structure Oncology Population study Observational study Female Neoplasm Grading business |
| Zdroj: | Cancer Reports, Vol 5, Iss 2, Pp n/a-n/a (2022) e1462 Cancer Reports |
| ISSN: | 2573-8348 |
| Popis: | Background Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) comprise a heterogeneous disease group. Factors that affect long-term survival remain uncertain. Complete population-representative cohorts with long-term follow-up are scarce. Aim To evaluate factors of importance for the long-term survival. Methods and results An Observational population-based study on consecutive GEP-NEN patients diagnosed from 2003 to 2013, managed according to national guidelines. Univariable and multivariable survival analyses were performed to evaluate overall survival (OS) and to identify independent prognostic factors. One hundred ninety eligible patients (males, 58.9%) (median age, 60.0 years; range, 10.0–94.2 years) were included. The small bowel, appendix, and pancreas were the most common tumor locations. The World Health Organization (WHO) tumor grade 1–3 distributions varied according to the primary location and disease stage. Primary surgery with curative intent was performed in 66% of the patients. The median OS of the study population was 183 months with 5- and 10-year OS rates of 66% and 57%, respectively. Only age, WHO tumor grade, and primary surgical treatment were independent prognostic factors for OS. Conclusion The outcomes of GEP-NEN patients are related to several factors including age and primary surgical treatment. WHO tumor grading, based on the established criteria, should be routine in clinical practice. This may improve clinical decision-making and allow the comparison of outcomes among different centers. publishedVersion |
| Databáze: | OpenAIRE |
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