Ortho-eugenol exhibits anti-nociceptive and anti-inflammatory activities
| Autor: | Adriana Maria Fernandes de Oliveira Golzio, Cynthia Germoglio Farias de Melo, José Maria Barbosa Filho, Diogo Vilar da Fonsêca, Liana Clébia de Morais Pordeus, Paula Regina Rodrigues Salgado, Fagner Carvalho Leite, Marcia Regina Piuvezam, Marcelo Ricardo Dutra Caldas Filho, Reinaldo Nóbrega de Almeida, Humberto de Carvalho Aragão Neto |
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| Rok vydání: | 2016 |
| Předmět: |
inorganic chemicals
0301 basic medicine Male Leukocyte migration Hot Temperature medicine.drug_class Immunology Interleukin-1beta Anti-Inflammatory Agents Adrenergic Pain Pharmacology Motor Activity p38 Mitogen-Activated Protein Kinases Anti-inflammatory Proinflammatory cytokine Capillary Permeability 03 medical and health sciences Mice Cell Movement Eugenol medicine Leukocytes Immunology and Allergy Animals Hot plate test Analgesics integumentary system Chemistry Tumor Necrosis Factor-alpha organic chemicals NF-kappa B Yohimbine Adrenergic alpha-2 Receptor Antagonists 030104 developmental biology Morphine bacteria Licking medicine.drug |
| Zdroj: | International immunopharmacology. 38 |
| ISSN: | 1878-1705 |
| Popis: | Ortho-eugenol is a much used phenylpropanoid whose ability to reduce pain and inflammation has never been studied. Researching ortho-eugenol's antinociceptive and anti-inflammatory activity, and its possible mechanisms of action is therefore of interest. The administration of vehicle, ortho-eugenol (50, 75 and 100mg/kg i.p.), morphine (6mg/kg, i.p.) or dexamethasone (2mg/kg, s.c.) occurred 30min before the completion of pharmacological tests. Pretreatment with ortho-eugenol did not change motor coordination test results, but reduced the number of writhes and licking times in the writhing test and glutamate test, respectively. The reaction time from thermal stimulus was significantly increased in the hot plate test after administration of ortho-eugenol. Treatment with yohimbine reversed the antinociceptive effect of ortho-eugenol, suggesting involvement of the adrenergic system. In anti-inflammatory tests, ortho-eugenol inhibited acetic acid induced vascular permeability and leukocyte migration, reducing TNF-α and IL-1β by virtue of its suppression of NF-κB and p38 phosphorylated forms in the peritonitis test. From these results, ortho-eugenol antinociceptive effects mediated by the adrenergic system and anti-inflammatory activity through regulation of proinflammatory cytokines and phosphorylation of NF-kB and p38 become evident for the first time. |
| Databáze: | OpenAIRE |
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