Age at onset of major depressive disorder in Han Chinese women: Relationship with clinical features and family history
| Autor: | Fuzhong Yang, Yihan Li, Dong Xie, Chunhong Shao, Jianer Ren, Wenyuan Wu, Ning Zhang, Zhen Zhang, Ying Zou, Jiulong Zhang, Dongdong Qiao, Chengge Gao, Youhui Li, Jian Hu, Hong Deng, Gang Wang, Bo Du, Xumei Wang, Tiebang Liu, Zhaoyu Gan, Juyi Peng, Bo Wei, Jiyang Pan, Honghui Chen, Shufan Sun, Hong Jia, Ying Liu, Qiaoling Chen, Xueyi Wang, Juling Cao, Luxian Lv, Yunchun Chen, Baowei Ha, Yuping Ning, YiPing Chen, Kenneth S. Kendler, Jonathan Flint, Shenxun Shi |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Research Report medicine.medical_specialty China Symptom Comorbidity Major depressive disorder behavioral disciplines and activities Phobic disorder Suicidal Ideation 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Family history Age of Onset Marriage Psychiatry Agoraphobia Depression (differential diagnoses) Depressive Disorder Depressive Disorder Major Dysthymic Disorder Mental Disorders Age at onset Middle Aged medicine.disease Prognosis Anxiety Disorders 3. Good health 030227 psychiatry Diagnostic and Statistical Manual of Mental Disorders Clinical Psychology Psychiatry and Mental health Logistic Models Phobic Disorders Female Age of onset Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Affective Disorders |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2011.06.056 |
| Popis: | BACKGROUND: Individuals with early-onset depression may be a clinically distinct group with particular symptom patterns, illness course, comorbidity and family history. This question has not been previously investigated in a Han Chinese population. METHODS: We examined the clinical features of 1970 Han Chinese women with DSM-IV major depressive disorder (MDD) between 30 and 60 years of age across China. Analysis of linear, logistic and multiple logistic regression models was used to determine the association between age at onset (AAO) with continuous, binary and discrete characteristic clinical features of MDD. RESULTS: Earlier AAO was associated with more suicidal ideation and attempts and higher neuroticism, but fewer sleep, appetite and weight changes. Patients with an earlier AAO were more likely to suffer a chronic course (longer illness duration, more MDD episodes and longer index episode), increased rates of MDD in their parents and a lower likelihood of marriage. They tend to have higher comorbidity with anxiety disorders (general anxiety disorder, social phobia and agoraphobia) and dysthymia. CONCLUSIONS: Early AAO in MDD may be an index of a more severe, highly comorbid and familial disorder. Our findings indicate that the features of MDD in China are similar to those reported elsewhere in the world. |
| Databáze: | OpenAIRE |
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