Synthesis and Characterization of Core–Shell Star Copolymers for In Vivo PET Imaging Applications
| Autor: | Ken-ichi Fukukawa, Eric D. Pressly, Craig J. Hawker, Karen L. Wooley, Benjamin Weaver Messmore, Aviv Hagooly, Michael J. Welch, Raffaella Rossin, Jasmine N. Hunt |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Biodistribution
Magnetic Resonance Spectroscopy Nanostructure Materials science Polymers and Plastics Polymers Surface Properties Shell (structure) Nanoparticle Bioengineering Polyethylene Glycols Rats Sprague-Dawley Biomaterials Heterocyclic Compounds 1-Ring chemistry.chemical_compound Living free-radical polymerization Polymer chemistry Materials Chemistry Copolymer Animals Tissue Distribution Drug Carriers Rats Copper Radioisotopes chemistry Chemical engineering Positron-Emission Tomography Nanoparticles Surface modification Female Ethylene glycol |
| Zdroj: | Biomacromolecules. 9:1329-1339 |
| ISSN: | 1526-4602 1525-7797 |
| Popis: | The synthesis of core-shell star copolymers via living free radical polymerization provides a convenient route to three-dimensional nanostructures having a poly(ethylene glycol) outer shell, a hydrophilic inner shell bearing reactive functional groups, and a central hydrophobic core. By starting with well-defined linear diblock copolymers, the thickness of each layer, overall size/molecular weight, and the number of internal reactive functional groups can be controlled accurately, permitting detailed structure/performance information to be obtained. Functionalization of these polymeric nanoparticles with a DOTA-ligand capable of chelating radioactive (64)Cu nuclei enabled the biodistribution and in vivo positron emission tomography (PET) imaging of these materials to be studied and correlated directly to the initial structure. Results indicate that nanoparticles with increasing PEG shell thickness show increased blood circulation and low accumulation in excretory organs, suggesting application as in vivo carriers for imaging, targeting, and therapeutic groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|