Dielectric and Biological Characterization of Liver Tissue in a High-Fat Diet Mouse Model
| Autor: | Clément Buisson, Lourdes Mounien, Flavie Sicard, Jean-François Landrier, Victoria Tishkova, Pierre Sabouroux |
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| Přispěvatelé: | Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
ex vivo tissues
[PHYS]Physics [physics] dielectric permittivity dielectric permittivity ex vivo tissues fatty and healthy liver triglyceride [SDV]Life Sciences [q-bio] fatty and healthy liver triglyceride Electrical and Electronic Engineering Biochemistry Instrumentation Atomic and Molecular Physics and Optics Analytical Chemistry |
| Zdroj: | Sensors Sensors, 2023, 23 (7), pp.3434. ⟨10.3390/s23073434⟩ |
| ISSN: | 1424-8220 |
| DOI: | 10.3390/s23073434⟩ |
| Popis: | International audience; Hepatic steatosis may be caused by type 2 diabetes or obesity and is one of the origins of chronic liver disease. A non-invasive technique based on microwave propagation can be a good solution to monitor hepatic tissue pathologies. The present work is devoted to the dielectric permittivity measurements in healthy and fatty liver in the microwave range. A mouse model following normal and high sugar/glucose (HFS) diets was used. We demonstrated the change in the triglyceride and glucose concentration in the hepatic tissue of HFS diet mice. The difference in the dielectric permittivity of healthy and fatty liver was observed in the range from 100 MHz to 2 GHz. The dielectric permittivity was found to be 42 in the healthy tissue and 31 in the fatty liver tissue at 1 GHz. The obtained results demonstrate that dielectric permittivity can be a sensitive tool to distinguish between healthy and fatty hepatic tissue. |
| Databáze: | OpenAIRE |
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