Targeted Oxygen in the Resuscitation of Preterm Infants, a Randomized Clinical Trial
| Autor: | Paul Craven, William Tarnow-Mordi, Meredith Ward, Kwee Ching See, Fook-Choe Cheah, Ju Lee Oei, Koert de Waal, Parag Mishra, Ian M. R Wright, Ola Didrik Saugstad, Javeed Travadi, Ahmed Masoud, Azanna Ahmad Kamar, Elisabeth Coates, Yao Mun Choo, Irene G.S. Cheah, Rowena L McMullan, Chin Theam Lim, Kei Lui, Yueping Alex Wang, John Smyth |
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| Rok vydání: | 2016 |
| Předmět: |
Risk
Male Resuscitation Pediatrics medicine.medical_specialty Ischemia Gestational Age law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law 030225 pediatrics Intensive Care Units Neonatal medicine Humans Oxidative injury 030212 general & internal medicine Oximetry Hospital Mortality business.industry Air Oxygen Inhalation Therapy Infant Newborn Gestational age Infant medicine.disease Disabled Children Increased risk Child Preschool Pediatrics Perinatology and Child Health Gestation Female Risk of death business Infant Premature Follow-Up Studies |
| Popis: | BACKGROUND AND OBJECTIVES: Lower concentrations of oxygen (O2) (≤30%) are recommended for preterm resuscitation to avoid oxidative injury and cerebral ischemia. Effects on long-term outcomes are uncertain. We aimed to determine the effects of using room air (RA) or 100% O2 on the combined risk of death and disability at 2 years in infants METHODS: A randomized, unmasked study designed to determine major disability and death at 2 years in infants RESULTS: Of 6291 eligible patients, 292 were recruited and 287 (mean gestation: 28.9 weeks) were included in the analysis (RA: n = 144; 100% O2: n = 143). Recruitment ceased in June 2014, per the recommendations of the Data and Safety Monitoring Committee owing to loss of equipoise for the use of 100% O2. In non-prespecified analyses, infants CONCLUSIONS: Using RA to initiate resuscitation was associated with an increased risk of death in infants |
| Databáze: | OpenAIRE |
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