The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population
| Autor: | Xing-chun Zhou, Xingli Wu, Wen-hui Chai, Ding-you Yang, Yu-sheng Zhao, Ming-lei Jin, Li Peng |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Coronary angiography 2D:4D medicine.medical_specialty CAD Coronary Artery Disease Fingers Coronary artery disease Sex Factors Internal medicine Humans Medicine diagnosis finger length ratio Chinese Anthropometry Receiver operating characteristic business.industry Area under the curve General Medicine Index finger medicine.disease Surgery medicine.anatomical_structure Cardiology Female coronary angiography business Student's t-test Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| DOI: | 10.7150/ijms.6360 |
| Popis: | Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women. Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD. Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p |
| Databáze: | OpenAIRE |
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