Psychiatric comorbidity in patients evaluated for chronic epilepsy: a differential role of the right hemisphere?

Autor: Francesca Sperli, Margitta Seeck, Fabienne Picard, Theodor Landis, Paul-André Despland, P. Jallon, Giovanni Foletti, Denis Rentsch
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Adult
Male
Obsessive-Compulsive Disorder
medicine.medical_specialty
Pediatrics
Psychotic Disorders/diagnosis/epidemiology
Comorbidity
Personality Disorders
Functional Laterality
Treatment Refusal
Epilepsy
Psychiatric comorbidity
Intellectual Disability
Interview
Psychological
medicine
Prevalence
Humans
Epilepsy surgery
In patient
Risk factor
Right hemisphere
Psychiatry
Cerebrum
Intellectual Disability/diagnosis/epidemiology
Depression (differential diagnoses)
Anxiety Disorders/diagnosis/epidemiology
Epilepsy/*epidemiology/surgery
Obsessive-Compulsive Disorder/diagnosis/epidemiology
business.industry
Mental Disorders
Mental Disorders/diagnosis/*epidemiology
Epilepsy
Temporal Lobe/epidemiology/surgery
Chronic epilepsy
medicine.disease
Anxiety Disorders
Cerebrum/*physiopathology
Temporal Lobe
ddc:616.8
Personality Disorders/diagnosis/epidemiology
Epilepsy
Temporal Lobe
Psychotic Disorders
Neurology
Female
Neurology (clinical)
Temporal Lobe/physiopathology
business
Zdroj: European Neurology, Vol. 61, No 6 (2009) pp. 350-357
ISSN: 0014-3022
Popis: Introduction: Psychiatric disorders are known to occur frequently in chronic epilepsy. The aim of this study is to investigate the prevalence of psychiatric comorbidity and its relationship to regional cerebral dysfunction in patients admitted to a tertiary epilepsy center for epilepsy surgery. Methods: 217 patients were investigated. A presurgical workup was performed and allowed precise localization of the epileptogenic focus in 156 patients. Sixty-one patients had multifocal or generalized discharges. After 1–3 psychiatric interviews, a psychiatric diagnosis was made (DSM-IV classification). Results: Psychiatric comorbidity was found in 85 patients (39%), more often in those with right or bilateral hemispheric dysfunction (74%, p = 0.04) with no difference between temporal or extratemporal foci location frequency. Additionally, patients with psychiatric disorders were less likely to undergo epilepsy surgery compared to ‘epilepsy-only’ patients (p = 0.003), despite similar good outcome in patients with and without psychiatric comorbidity. Conclusions: Right-sided or bilateral foci seem to represent a risk factor for psychiatric comorbidity in epilepsy, although we did not find any particular association between a psychiatric syndrome and focus localization. Recognition and treatment of psychiatric comorbidity is of major importance since its presence may interfere with patient’s decision making for epilepsy surgery treatment.
Databáze: OpenAIRE
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