INTRAMUSCULAR ADMINISTRATION OF KETAMINE-MEDETOMIDINE ASSURES STABLE ANAESTHESIA NEEDED FOR LONG-TERM SURGERY IN THE ARGENTINE TEGUSALVATOR MERIANAE
| Autor: | Anthony Herrel, Johanna Roux, Baptiste Barrillot, Angeline Clair, Paul-Antoine Libourel, Sébastien Arthaud, Laëtitia Averty |
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| Přispěvatelé: | Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Plate-Forme de Recherche en Imagerie Cellulaire de Haute-Normandie (PRIMACEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Evolutionary Morphology of Vertebrates, Universiteit Gent = Ghent University [Belgium] (UGENT), Mécanismes adaptatifs : des organismes aux communautés (MAOAC), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Rok vydání: | 2018 |
| Předmět: |
Male
0106 biological sciences medicine.medical_specialty 040301 veterinary sciences Tegu Injections Intramuscular 010603 evolutionary biology 01 natural sciences 0403 veterinary science Salvator merianae Interquartile range medicine Animals Hypnotics and Sedatives Anesthesia Ketamine ComputingMilieux_MISCELLANEOUS Anesthetics Dissociative Dose-Response Relationship Drug General Veterinary business.industry Atipamezole Lizards 04 agricultural and veterinary sciences General Medicine Medetomidine 3. Good health Surgery Drug Combinations [SDE]Environmental Sciences Anesthetic Female Animal Science and Zoology [SDE.BE]Environmental Sciences/Biodiversity and Ecology business Intramuscular injection medicine.drug |
| Zdroj: | Journal of Zoo and Wildlife Medicine Journal of Zoo and Wildlife Medicine, American Association of Zoo Veterinarians, 2018, 49 (2), pp.291-296. ⟨10.1638/2017-0089.1⟩ |
| ISSN: | 1937-2825 1042-7260 |
| DOI: | 10.1638/2017-0089.1 |
| Popis: | To define a protocol of anesthesia for long-duration invasive surgery in a lizard, eight young adult Argentine tegus ( Salvator merianae) of mean body weight 3.0 kg (interquartile range [IQR] 3.40-2.65) were anesthetized with a mixture of ketamine (K) and medetomidine (M) at 19°C, injected intramuscularly and equally distributed in the four limbs. As the experimental surgery procedure required a prolonged deep anesthesia with a good myorelaxation (between 16 and 21 hr), reinjections were required and reflexes were checked during surgery. Times for anesthetic induction, anesthetic reinjection, and recovery periods were recorded for five different combinations of ketamine-medetomidine: 1) 66 mg/kg K + 100 μg/kg M; 2) 80 mg/kg K + 100 μg/kg M; 3) 100 mg/kg K + 130 μg/kg M; 4) 125 mg/kg K + 200 μg/kg M; and 5) 150 mg/kg K + 200 μg/kg M. The effect on the recovery speed of the postoperative atipamezole injection was also evaluated. The median induction time was 30 (IQR 35-27.5) min with no statistical difference between all the concentrations tested. The first reinjection of half a dose was administered after a mean of 5 hr (5.64 hr, IQR 5.95-4.84) as were the subsequent reinjections of a quarter dose (3.99 hr, IQR 5.98-3.23). Intramuscular administration of the ketamine-medetomidine combination is a simple, rapid, and efficient anesthesia for long-term surgery (12 hr). A mix of 100 mg/kg ketamine and 200 μg/kg medetomidine, with reinjections every 4 hr of half a dose of the previous injection can maintain a good quality of anesthesia for at least 16 hr. The injection of atipamezole after the surgery reverses the effects of medetomidine and permits a reduction of the recovery period. |
| Databáze: | OpenAIRE |
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