Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
| Autor: | Petra Spidlova, Jiri Stulik, Pavla Stojkova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) DNA Bacterial Mini Review 030106 microbiology Immunology HU Protein lcsh:QR1-502 Virulence DNA-binding protein Biology Microbiology lcsh:Microbiology 03 medical and health sciences Cellular and Infection Microbiology Bacterial Proteins Nucleoid SOS response Gene Regulation of gene expression pathogenesis DNA Gene Expression Regulation Bacterial nucleoid-associated protein Cell biology HU protein DNA-Binding Proteins virulence 030104 developmental biology Infectious Diseases DNA supercoil Protein Processing Post-Translational Protein Binding |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 9 (2019) Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2019.00159/full |
| Popis: | Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial cells. These transcription regulators are responsible for many important cellular processes and also are involved in pathogenesis of bacteria. The best-known nucleoid-associated proteins, such as HU, FIS, H-NS, and IHF, are often discussed. The most important findings in research concerning HU protein are described in this mini review. Its roles in DNA compaction, shape modulation, and negative supercoiling induction have been studied intensively. HU protein regulates bacteria survival, growth, SOS response, virulence genes expression, cell division, and many other cell processes. Elucidating the mechanism of HU protein action has been the subject of many research projects. This mini review provides a comprehensive overview of the HU protein. |
| Databáze: | OpenAIRE |
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