P300 amplitude over temporal regions in schizophrenia
| Autor: | Yuka Okajima, Kazuyuki Nakagome, Tsuyoshi Araki, Kunitoshi Kamijima, Akira Iwanami, Shunichi Furukawa, Hiroshi Isono, Satoru Kamio, Nobumasa Kato, Kiyoto Kasai, Masato Fukuda |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Neuropsychological Tests Audiology Temporal lobe Developmental psychology Risk Factors P3b Reaction Time medicine Humans Pharmacology (medical) Latency (engineering) Antipsychotic Oddball paradigm Biological Psychiatry Electroencephalography Cognition General Medicine medicine.disease Event-Related Potentials P300 Temporal Lobe Psychiatry and Mental health Amplitude Schizophrenia Evoked Potentials Auditory Female Schizophrenic Psychology Analysis of variance Psychology Cognitive psychology |
| Zdroj: | European Archives of Psychiatry and Clinical Neuroscience. 252:1-7 |
| ISSN: | 1433-8491 0940-1334 |
| Popis: | To examine the left temporal scalp area reductions of P300 amplitude, event-related potentials (ERPs) during a standard oddball task were recorded in 57 schizophrenic patients and 33 normal controls. The P300 amplitude at T3 was not significantly smaller than that at T4 in schizophrenic patients. In the ANOVA analysis of the P300 peak amplitude and PCA factor scores, significant lateral topographical differences in P300 were not present between patients and controls. However, in schizophrenia, patients in the low T3 P300 group were older and consuming higher doses of antipsychotic medicine than those in the high T3 P300 group, and they had relatively low P300 amplitudes and significantly delayed P300 latency, compared with those in the high T3 P300 group. These findings suggested that although the reduction in the left temporal P300 amplitude did not necessarily exist in schizophrenic patients, it may be associated with the severity of the disease process and/or impairment of cognitive function. |
| Databáze: | OpenAIRE |
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