Genotoxicity of mixtures of glyphosate with 2,4-dichlorophenoxyacetic acid chemical forms towards Cnesterodon decemmaculatus (Pisces, Poeciliidae)
| Autor: | Celeste Ruiz de Arcaute, Marcelo L. Larramendy, Luciano Torres, Wanessa Fernandes Carvalho, Sonia Soloneski, Daniela de Melo e Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Glyphosate
2 4-Dichlorophenoxyacetic acid Health Toxicology and Mutagenesis Glycine GLYPHOSATE 010501 environmental sciences 2 4-D Herbicide mixtures medicine.disease_cause 01 natural sciences purl.org/becyt/ford/1 [https] Cyprinodontiformes chemistry.chemical_compound medicine Animals Ciencias Naturales Environmental Chemistry Bioassay Ecotoxicology Food science Mortality purl.org/becyt/ford/1.6 [https] 0105 earth and related environmental sciences Gel electrophoresis Poeciliidae biology Herbicides Mutagenicity Tests Chemistry MORTALITY SCGE (comet) assay SCGE (COMET) ASSAY General Medicine biology.organism_classification Pollution Toxicity HERBICIDE MIXTURES 2 4-Dichlorophenoxyacetic Acid Water Pollutants Chemical Genotoxicity |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| DOI: | 10.1007/s11356-019-07379-x |
| Popis: | Acute genotoxicity of commercial glyphosate (GLY) (Credit®)-, 2,4-D-acid (2,4-D) (Dedalo Elite)-, 2,4-D-amine (2,4-D DMA) (Weedar Full®)- and 2,4-D-ester (2,4-D BE) (Herbifen Super®)-based herbicide formulations alone and their combinations were analysed in Cnesterodon decemmaculatus. Mortality was evaluated as a lethal end-point and the single cell gel electrophoresis (SCGE) bioassay was used as a sublethal end-point. LC50₉₆ₕ values for Dedalo Elite was 0.46 mg/L and Herbifen Super® was 2.67 mg/L based on 2,4-D and 2,4-D BE, respectively. Results reveal a higher toxicity exerted on C. decemmaculatus after exposure to 2,4-D- rather than 2,4-D BE-based herbicide formulations. Overall, results demonstrated an enhancement in the genetic damage index committed to an enhancement of damaged erythrocytes of C. decemmaculatus when exposed to Credit®, Dedalo Elite, Weedar Full® and Herbifen Super® at 5% and 10% of LC50₉₆ₕ values alone as well as in their combinations. Overall, the combination of GLY plus 2,4-D or GLY plus 2,4-D DMA showed a synergistic pattern whereas the combination of GLY plus 2,4-D BE was antagonic. Furthermore, this research is pioneer in the assessment of lethality and genotoxicity induced by 2,4-D-, 2,4-D DMA- and 2,4-D BE-based formulations when combined with GLY-based formulated herbicides in fish after they are acutely exposed. Facultad de Ciencias Naturales y Museo |
| Databáze: | OpenAIRE |
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