A familial cluster of COVID-19 infection in a northern Chinese region

Autor: Lu-yao Sun, Cai-xia Liu, Yi-zhe Sun, Kai-yu Zhang, Zhi-hui Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
China
2019-nCoV
2019 novel coronavirus
RT-PCR
reverse transcription-polymerase chain reaction
WBCs
white blood cells
Infectious and parasitic diseases
RC109-216
Disease cluster
medicine.disease_cause
ACE2
angiotensin-converting enzyme 2
WHO
World Health Organization
law.invention
Incubation period
Disease Outbreaks
law
Internal medicine
Epidemiology
Quarantine
Global health
medicine
Humans
Coronavirus
COVID-19
coronavirus disease 2019
ESR
erythrocyte sedimentation rate
SARS-CoV-2
severe acute respiratory coronavirus 2
Coronavirus disease 2019
business.industry
SARS-CoV-2
Family cluster
Public Health
Environmental and Occupational Health
Outbreak
COVID-19
General Medicine
Infectious Diseases
NCP
Novel Coronavirus Pneumonia
CRP
C-reactive protein
CT
Computed tomography
Original Article
Public aspects of medicine
RA1-1270
business
Asymptomatic carrier
Zdroj: Journal of Infection and Public Health, Vol 14, Iss 9, Pp 1127-1132 (2021)
Journal of Infection and Public Health
ISSN: 1876-0341
Popis: Objective Currently, coronavirus disease 2019 (COVID-19) has spread worldwide and become a global health concern. Here, we report a familial cluster of six patients infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) in a northern Chinese region and share our local experience with regard the control of COVID-19. Methods The demographic data, clinical features, laboratory examinations, and epidemiological characteristics of enrolled cases were collected and analyzed. Two family members (Cases 1 and 2) had Hubei exposure history and were admitted to the hospital with a confirmed diagnosis of COVID-19; eight familial members who had contact with them during the incubation period underwent quarantine in a hospital. We closely followed up all the family members and analyzed their clinical outcome. Results Case 3 had negative SARS-CoV-2 reverse transcription-polymerase chain reaction (RT-PCR) results but was suspected to have COVID-19 because of radiographic abnormalities. Cases 4 and 5 developed symptomatic COVID-19. Case 6 was considered an asymptomatic carrier as his SARS-CoV-2 RT-PCR result was positive. The other four family members with close contacts to COVID-19 patients had no evidence of SARS-CoV-2 infection. Conclusions Our findings suggest that COVID-19 has infectivity during the incubation period and preventive quarantine is effective for controlling an outbreak of COVID-19 infection.
Databáze: OpenAIRE
Externí odkaz: