Effects of a short-term overfeeding with fructose or glucose in healthy young males
| Autor: | Emilienne Tudor Ngo Sock, Luc Tappy, Kim-Anne Lê, Michael Ith, Roland Kreis, Chris Boesch |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty 030309 nutrition & dietetics medicine.medical_treatment Cholesterol VLDL Medicine (miscellaneous) Blood sugar 030209 endocrinology & metabolism Fructose Biology Young Adult 03 medical and health sciences chemistry.chemical_compound Overnutrition 0302 clinical medicine Dietary Sucrose Internal medicine medicine Humans Insulin Intramyocellular lipids Triglycerides Pancreatic hormone Muscle Cells 0303 health sciences Nutrition and Dietetics Cholesterol Alanine Transaminase/blood Blood Glucose/metabolism Cholesterol VLDL/blood Diet Dietary Sucrose/administration & dosage Energy Intake Fasting Fructose/administration & dosage Glucose/administration & dosage Insulin/blood Lipid Metabolism Liver/drug effects Liver/metabolism Muscle Cells/drug effects Muscle Cells/metabolism Overnutrition/metabolism Triglycerides/blood Alanine Transaminase Lipid metabolism Metabolism Glucose Endocrinology Liver chemistry |
| Zdroj: | British Journal of Nutrition British Journal of Nutrition, vol. 103, no. 7, pp. 939-943 Ngo Sock, Emilienne Tudor; Lê, Kim-Anne; Ith, Michael; Kreis, Roland; Boesch, Chris; Tappy, Luc (2010). Effects of a short-term overfeeding with fructose or glucose in healthy young males. British journal of nutrition, 103(7), pp. 939-43. Cambridge: Cambridge University Press 10.1017/S0007114509992819 |
| DOI: | 10.1017/S0007114509992819 |
| Popis: | Consumption of simple carbohydrates has markedly increased over the past decades, and may be involved in the increased prevalence in metabolic diseases. Whether an increased intake of fructose is specifically related to a dysregulation of glucose and lipid metabolism remains controversial. We therefore compared the effects of hypercaloric diets enriched with fructose (HFrD) or glucose (HGlcD) in healthy men. Eleven subjects were studied in a randomised order after 7 d of the following diets: (1) weight maintenance, control diet; (2) HFrD (3·5 g fructose/kg fat-free mass (ffm) per d, +35 % energy intake); (3) HGlcD (3·5 g glucose/kg ffm per d, +35 % energy intake). Fasting hepatic glucose output (HGO) was measured with 6,6-2H2-glucose. Intrahepatocellular lipids (IHCL) and intramyocellular lipids (IMCL) were measured by1H magnetic resonance spectroscopy. Both fructose and glucose increased fasting VLDL-TAG (HFrD: +59 %,P P = 0·11) and IHCL (HFrD: +52 %,P P = 0·06). HGO increased after both diets (HFrD: +5 %,P P = 0·05). No change was observed in fasting glycaemia, insulin and alanine aminotransferase concentrations. IMCL increased significantly only after the HGlcD (HFrD: +24 %, NS; HGlcD: +59 %,P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|