The impact of oral Polypodium leucotomos extract on ultraviolet B response: a human clinical study
| Autor: | Iltefat H. Hamzavi, Craig A. Elmets, Prescilia Isedeh, Narumol Silpa-archa, M. Athar, Rubina Shafi, Henry W. Lim, Indermeet Kohli, Nikiforos Kollias, James L. Griffith, Mohammed Al-Jamal, Bradford E. Jackson |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Polypodium Ultraviolet Rays Administration Oral Dermatology Article Clinical study 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Oral administration medicine Ingestion Humans Polypodium Leucotomos Fitzpatrick Skin Phototype I Skin business.industry Plant Extracts Ultraviolet b Regimen 030220 oncology & carcinogenesis Photoprotection Female business |
| Popis: | Background There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen. Objective This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE). Methods In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE. Results Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects. Limitations Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied. Conclusion The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB. |
| Databáze: | OpenAIRE |
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