Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro
| Autor: | Shivaji V. More, Chung-Kuang Lu, Wen-Shan Li, Ya Ching Jen, Ting-Ju Chen, I.-Hsuan Lu, Jui-Ching Hsu, Tzu Ting Chang |
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| Rok vydání: | 2011 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Magnetic Resonance Spectroscopy Spectrophotometry Infrared Blotting Western Spectrometry Mass Fast Atom Bombardment Lyngbya Cell Movement Cell Line Tumor Neoplasms Drug Discovery Humans Tumor Cell Migration Pyrroles Neoplasm Metastasis Protein kinase B Pharmacology Cell invasion biology Chemistry Integrin beta1 Organic Chemistry General Medicine biology.organism_classification Amides In vitro Biochemistry Focal Adhesion Protein-Tyrosine Kinases Cancer research Proto-Oncogene Proteins c-akt |
| Zdroj: | European Journal of Medicinal Chemistry. 46:3810-3819 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2011.05.049 |
| Popis: | Isomalyngamide A ( 1 ) and A-1 ( 2 ) were isolated from the Taiwanese Lyngbya majuscule and the latter structure was elucidated by a combination of NMR spectroscopic analysis and HRESIMS measurement. We report the isolation of isomalyngamide A ( 1 ), discovery of isomalyngamide A-1 ( 2 ) and their synthetic analogs ( 3 – 9 ), which are further demonstrated to have therapeutic potential against tumor cell migration at the level of nanomolar to micromolar ranges, perhaps, by inactivating the expression of p -FAK, FAK, p -Akt and Akt through β1 integrin-mediated antimetastatic pathway. |
| Databáze: | OpenAIRE |
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