Assessment of health related quality of life in polish patients with primary biliary cirrhosis
| Autor: | Gary L. Norman, Ewa Wunsch, Marek Krawczyk, Joanna Raszeja-Wyszomirska, Dimitrios P. Bogdanos, Piotr Milkiewicz, Konrad Kostrzewa, Eirini I. Rigopoulou |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty digestive system 03 medical and health sciences Sex Factors 0302 clinical medicine Primary biliary cirrhosis Quality of life Disease severity Sex factors Surveys and Questionnaires Internal medicine Female patient Humans Medicine Cognitive Dysfunction skin and connective tissue diseases Fatigue Autoantibodies Health related quality of life Hepatology Liver Cirrhosis Biliary business.industry Pruritus Gastroenterology Case-control study Middle Aged medicine.disease humanities digestive system diseases Nuclear Pore Complex Proteins Case-Control Studies 030220 oncology & carcinogenesis Quality of Life Female 030211 gastroenterology & hepatology Poland business |
| Zdroj: | Clinics and Research in Hepatology and Gastroenterology. 40:471-479 |
| ISSN: | 2210-7401 |
| DOI: | 10.1016/j.clinre.2015.10.006 |
| Popis: | Summary Background Most patients with primary biliary cirrhosis (PBC) have impaired health related quality of life (HRQoL), as assessed by PBC-specific HRQoL (PBC-40) and generic (SF-36) questionnaires. Data on the applicability of PBC-27, a shorter version of PBC-40, have been limited. Aims To assess HRQoL in Polish PBC patients, applying PBC-40, PBC-27 and SF-36 and to associate clinical or laboratory parameters with HRQoL factors. Methods A total of 205 PBC patients (188 females) were analyzed using PBC-40, PBC-27 and SF-36; 85 disease-free demographically matched (in terms of age, gender, ethnicity) individuals were used as normal controls. Results When compared to controls, PBC patients had significantly impaired HRQoL across all the domains of SF-36. HRQoL impairment by PBC-40 and PBC-27 was comparable between cirrhotics and non-cirrhotics, except for significantly worse Itch in cirrhotics (6.5 ± 4.9 vs 5.1 ± 4.3; P = 0.03). In PBC-40/27, alkaline phosphatase (ALP) levels correlated with itch (P = 0.0003). Female patients had marginally impaired cognitive function compared to males by PBC-40 (P = 0.06). Other gender-related differences were not found. Anti-gp210 positive, as well as AMA negative PBC patients, had worse HRQoL features in itch and social/emotional domains of PBC-40/PBC-27 questionnaires. Very strong correlations (P Conclusions HRQoL is significantly impaired in Polish patients with PBC, independently of gender and disease severity. PBC-40 and PBC-27 questionnaires are efficient in detecting HRQoL impairment in Polish PBC patients. The striking correlation between PBC-40/PBC-27 and SF-36 confirms the usefulness of the former HRQoL measures in PBC patients from Central-Eastern Europe. |
| Databáze: | OpenAIRE |
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