Common variable immunodeficiency syndrome with chronic diarrhoea
| Autor: | Mukesh Nasa, Randhir Sud, Lipika Lipi, Smruti R. Mishra |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Diarrhea Male 0301 basic medicine Duodenum Congenital cytomegalovirus infection medicine.disease_cause Antiviral Agents Asymptomatic Lymphoid hyperplasia 03 medical and health sciences 0302 clinical medicine Rare Disease Intestine Small Humans Medicine Giardia lamblia Large intestine Endoscopy Digestive System Ganciclovir Immunodeficiency Hyperplasia business.industry Common variable immunodeficiency Immunoglobulins Intravenous General Medicine Middle Aged medicine.disease Lymphoproliferative Disorders Small intestine Common Variable Immunodeficiency Treatment Outcome 030104 developmental biology medicine.anatomical_structure Cytomegalovirus Infections Immunology 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2018-228240 |
| Popis: | Common variable immunodeficiency syndrome (CVID) is a heterogeneous disorder characterised by diminished levels of IgG, IgA and/or IgM, and recurrent bacterial infections. Sinopulmonary infections are most commonly reported followed by gastrointestinal (GI) infections. GI tract represents the largest immune organ with abundance of lymphoid cells, its involvement can manifest variably ranging from asymptomatic involvement to florid symptoms and signs. Diffuse nodular lymphoid hyperplasia (DNLH) of the GI tract is characterised by numerous small polypoid nodules of variable size in the small intestine, large intestine or both. It is commonly seen in association to immunodeficiency states such as CVID, IgA deficiency and chronic infections due to Giardia lamblia and Helicobacter pylori and cryptosporidiosis. Repetitive antigenic stimulation leads to lymphoid hyperplasia. We herein describe a case of DNLH of the intestine and another case of duodenal cytomegalovirus (CMV) infection associated with CVID. |
| Databáze: | OpenAIRE |
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