Chronic ethanol feeding causes accumulation of serum cholesterol in rat pancreas
| Autor: | Ron Pirola, John B. Somer, Jeremy S. Wilson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Mevalonic Acid Mevalonic acid Acetates Biology Pathology and Forensic Medicine chemistry.chemical_compound Internal medicine medicine Animals Pancreas Molecular Biology Acetic Acid chemistry.chemical_classification Ethanol Cholesterol Body Weight Pancreatic Diseases Fatty acid Rats Inbred Strains Organ Size medicine.disease Sterol Rats Endocrinology medicine.anatomical_structure chemistry Cholesteryl ester Female lipids (amino acids peptides and proteins) Cholesterol Esters Steatosis |
| Zdroj: | Experimental and Molecular Pathology. 41:289-297 |
| ISSN: | 0014-4800 |
| Popis: | In a previous study, a rat model of ethanol-induced pancreatic steatosis was developed in which chronic ethanol feeding resulted in a twofold increase in pancreatic cholesteryl ester content. The studies reported here were performed in order to elucidate the mechanism of this cholesteryl ester accumulation. Rats were pair fed ethanol or control diets for 3 weeks. Ethanol feeding resulted in an increased accumulation of serum cholesterol in the pancreas. Ethanol feeding also resulted in increased in vitro incorporation of labeled acetate and mevalonate into the sterol moiety of pancreatic cholesteryl ester and increased incorporation of labeled acetate into its fatty acid component. These results suggest that chronic ethanol feeding causes pancreatic cholesteryl ester accumulation by affecting exchange of cholesterol between serum and pancreatic tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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