Quantifying the role of PSA screening in the US prostate cancer mortality decline
Autor: | Angela B. Mariotto, David F. Penson, Eric J. Feuer, Jake Wegelin, Alexander Tsodikov, Ruth Etzioni, Seth Falcon, Roman Gulati, Aniko Szabo, Dante diTommaso, Kent Karnofski |
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Rok vydání: | 2007 |
Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Psa screening Article Prostate cancer Internal medicine Epidemiology of cancer Epidemiology medicine Humans Mass Screening Mass screening Aged Aged 80 and over Cancer mortality business.industry Prostatic Neoplasms Middle Aged Models Theoretical Prostate-Specific Antigen medicine.disease United States Prostate-specific antigen US Prostate business Forecasting SEER Program |
Zdroj: | Cancer Causes & Control. 19:175-181 |
ISSN: | 1573-7225 0957-5243 |
Popis: | To quantify the plausible contribution of prostate-specific antigen (PSA) screening to the nearly 30% decline in the US prostate cancer mortality rate observed during the 1990s.Two mathematical modeling teams of the US National Cancer Institute's Cancer Intervention and Surveillance Modeling Network independently projected disease mortality in the absence and presence of PSA screening. Both teams relied on Surveillance, Epidemiology, and End Results (SEER) registry data for disease incidence, used common estimates of PSA screening rates, and assumed that screening, by shifting disease from distant to local-regional clinical stage, confers a corresponding improvement in disease-specific survival.The teams projected similar mortality increases in the absence of screening and decreases in the presence of screening after 1985. By 2000, the models projected that 45% (Fred Hutchinson Cancer Research Center) to 70% (University of Michigan) of the observed decline in prostate cancer mortality could be plausibly attributed to the stage shift induced by screening.PSA screening may account for much, but not all, of the observed drop in prostate cancer mortality. Other factors, such as changing treatment practices, may also have played a role in improving prostate cancer outcomes. |
Databáze: | OpenAIRE |
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