An Observational Study of 11 French Liver Transplant Recipients Infected with Human Immunodeficiency Virus Type 1
| Autor: | P. Debat, A. G. Saimot, François Simon, H. Bismuth, F. Bouscarat, Didier Samuel |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Graft Rejection Male Microbiology (medical) medicine.medical_specialty Blood transfusion Adolescent medicine.medical_treatment Liver transplantation Acquired immunodeficiency syndrome (AIDS) Internal medicine Immunopathology medicine Humans Sida Survival rate Acquired Immunodeficiency Syndrome biology business.industry Middle Aged biology.organism_classification medicine.disease CD4 Lymphocyte Count Liver Transplantation Surgery Transplantation Infectious Diseases HIV-1 Female Viral disease business Follow-Up Studies |
| Zdroj: | Clinical Infectious Diseases. 19:854-859 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/clinids/19.5.854 |
| Popis: | We report the clinical and biological course of infection with human immunodeficiency virus (HIV) type 1 in 11 liver transplant recipients who acquired this infection between 1985 and 1987. Eight patients were infected by blood or blood products from graft-related transfusions and one by the graft itself; the remaining two patients were infected after transplantation and had independent risk factors. All patients received a triple-drug immunosuppressive regimen including cyclosporine. The mean duration of follow-up after liver transplantation was 52 months (standard error, +/- 32 months). Chronic graft rejection was documented in four cases. The cumulative incidences of HIV-related complications and HIV-related deaths were 82% and 27%, respectively. Three patients died rapidly of HIV disease. The survival rate 7 years after transplantation was 36% among the 11 HIV-infected patients, whereas it was approximately 70% among HIV-negative liver transplant recipients during the same period. The course of HIV infection in the four survivors did not appear to differ from that in other patients infected by blood transfusion. |
| Databáze: | OpenAIRE |
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