Childhood trauma, psychiatric disorders, and criminality in women: Associations with serum levels of brain-derived neurotrophic factor
| Autor: | Helena Dias de Castro Bins, Renata Maria Dotta Panichi, Ygor Arzeno Ferrão, José Geraldo Vernet Taborda |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Hospitals Psychiatric Child abuse medicine.medical_specialty Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Adverse Childhood Experiences Neurotrophic factors Surveys and Questionnaires Healthy control Humans Medicine Psychiatry Psychological abuse Physical neglect 0505 law Psychiatric Status Rating Scales Brain-derived neurotrophic factor business.industry Adult Survivors of Child Abuse Brain-Derived Neurotrophic Factor Mental Disorders 05 social sciences Criminals Middle Aged Mental illness medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Sexual abuse Criminal Behavior 050501 criminology Female Crime business Law Brazil |
| Zdroj: | International Journal of Law and Psychiatry. 71:101574 |
| ISSN: | 0160-2527 |
| DOI: | 10.1016/j.ijlp.2020.101574 |
| Popis: | Psychiatric disorders and childhood trauma are highly prevalent in female inmates. Brain-derived neurotrophic factor (BDNF) plays a number of roles in neuronal survival, structure, and function. Data in the literature suggest that it is a neurobiological substrate that moderates the impact of childhood adversities on the late expression of psychiatric disorders. The aim of this study was to determine whether five childhood trauma subtypes-physical abuse, sexual abuse, emotional abuse, physical neglect, and emotional neglect-are associated with adult psychiatric disorders, BDNF levels, and criminality among incarcerated women. This was a cross-sectional study involving a consecutive sample of 110 women, divided into three groups of women (forensic - mentally ill who committed crimes, clinical psychiatric inpatients and healthy controls). The Childhood Trauma Questionnaire and the Mini-International Neuropsychiatric Interview-Plus were applied in the whole sample, and BDNF levels were measured in a sub-sample of 54 women. The rates of mental illness and childhood trauma were high in the forensic group. Emotional abuse was higher in the clinical and forensic groups than in the healthy control group. Lower BDNF levels were associated with emotional abuse in the forensic group as well as with sexual abuse in the healthy control group. After multinomial logistic regression, lower levels of BDNF, higher levels of emotional abuse and the presence of familial offense were considered factors related to clinical psychiatric group. The results of this study underscore the idea that BDNF may be an important factor related to the development of diseases and criminality in women who are victims of childhood trauma, becoming a possible biological marker. |
| Databáze: | OpenAIRE |
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