Toxicokinetics of fumonisin B1 in turkey poults and tissue persistence after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds
| Autor: | François Grosjean, Fabien Skiba, P. Guerre, D. Tardieu, Jean Denis Bailly |
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| Přispěvatelé: | Ecole Nationale Vétérinaire de Toulouse - ENVT (FRANCE), ARVALIS - Institut du végétal (FRANCE) |
| Rok vydání: | 2008 |
| Předmět: |
Male
Turkeys Biology Toxicology medicine.disease_cause Fumonisins Fumonisin B1 Food safety Persistence (computer science) chemistry.chemical_compound Animal science Oral administration medicine Animals Toxicokinetics Tissue Distribution European Union Mycotoxin Chromatography High Pressure Liquid Toxicologie Turkey poults Toxin General Medicine Animal Feed Toxicokinetic Carcinogens Environmental Diet Bioavailability chemistry Area Under Curve Data Interpretation Statistical Injections Intravenous Tissue residues Toxicity Half-Life Food Science |
| Zdroj: | Food and Chemical Toxicology. 46:3213-3218 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2008.07.013 |
| Popis: | The kinetic of fumonisin B1 (FB1) after a single IV and oral dose, and FB1 persistence in tissue were investigated in turkey poults by HPLC after purification of samples on columns. After IV administration (single-dose: 10 mg FB1/kg bw), serum concentration–time curves were best described by a three-compartment open model. Elimination half-life and mean residence time of FB1 were 85 and 52 min, respectively. After oral administration (single-dose: 100 mg FB1/kg bw) bioavailability was 3.2%; elimination half-life and mean residence time were 214 and 408 min, respectively. Clearance of FB1 was 7.6 and 7.5 ml/min/kg for IV and oral administration, respectively. Twenty-four hours after the administration of FB1 by the intravenous route, liver and kidney contained the highest levels of FB1 in tissues, level in muscle was low or below the limit of detection (LD, 13 μg/kg). The persistence of FB1 in tissue was also studied after administration for 9 weeks of a feed that contained 5, 10 and 20 mg FB1 + FB2/kg diet. Eight hours after the last intake of 20 mg FB1+FB2/kg feed (maximum recommended concentration of fumonisins established by the EU for avian feed), hepatic and renal FB1 concentrations were 119 and 22 μg/kg, level in muscles was below the LD. |
| Databáze: | OpenAIRE |
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