Single molecule detection, thermal fluctuation and life
| Autor: | Yoshiharu Ishii, Toshio Yanagida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Models
Molecular Engineering Flexibility (anatomy) thermal noise Protein Conformation General Physics and Astronomy Review Myosins 010402 general chemistry 01 natural sciences molecular motors Thermal molecular machines medicine Molecule Animals Humans Simulation Brownian motion Mechanical Phenomena Protein molecules 010405 organic chemistry business.industry Temperature General Medicine Molecular machine Single Molecule Imaging 0104 chemical sciences single molecule detection thermal fluctuation medicine.anatomical_structure signaling processes General Agricultural and Biological Sciences Biological system business |
| Zdroj: | Proceedings of the Japan Academy. Series B, Physical and Biological Sciences |
| ISSN: | 1349-2896 0386-2208 |
| Popis: | Single molecule detection has contributed to our understanding of the unique mechanisms of life. Unlike artificial man-made machines, biological molecular machines integrate thermal noises rather than avoid them. For example, single molecule detection has demonstrated that myosin motors undergo biased Brownian motion for stepwise movement and that single protein molecules spontaneously change their conformation, for switching to interactions with other proteins, in response to thermal fluctuation. Thus, molecular machines have flexibility and efficiency not seen in artificial machines. |
| Databáze: | OpenAIRE |
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