State-of-the-Art Dermatophyte Infections: Epidemiology Aspects, Pathophysiology, and Resistance Mechanisms
Autor: | Nilce Maria Martinez-Rossi, Tamires Aparecida Bitencourt, Maíra Pompeu Martins, Nalu T. A. Peres, Antonio Rossi |
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Rok vydání: | 2021 |
Předmět: |
virulence traits
0301 basic medicine Microbiology (medical) medicine.medical_specialty dermatophytosis QH301-705.5 030106 microbiology Population Review resistance mechanisms Plant Science Trichophyton rubrum Dermatomycosis medicine.disease_cause 03 medical and health sciences fungal-host interaction Trichophyton Epidemiology medicine Biology (General) education transcription factor Ecology Evolution Behavior and Systematics education.field_of_study biology Resistance (ecology) business.industry biology.organism_classification keratin degradation Trichophyton interdigitale 030104 developmental biology cutaneous infection Immunology Dermatophyte business EPIDEMIOLOGIA |
Zdroj: | Journal of Fungi, Vol 7, Iss 629, p 629 (2021) Journal of Fungi Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
ISSN: | 2309-608X |
Popis: | The burden of fungal infections is not widely appreciated. Although these infections are responsible for over one million deaths annually, it is estimated that one billion people are affected by severe fungal diseases. Mycoses of nails and skin, primarily caused by fungi known as dermatophytes, are the most common fungal infections. Trichophyton rubrum appears to be the most common causative agent of dermatophytosis, followed by Trichophyton interdigitale. An estimated 25% of the world’s population suffers from dermatomycosis. Although these infections are not lethal, they compromise the quality of life of infected patients. The outcome of antidermatophytic treatments is impaired by various conditions, such as resistance and tolerance of certain dermatophyte strains. The adage “know your enemy” must be the focus of fungal research. There is an urgent need to increase awareness about the significance of these infections with precise epidemiological data and to improve knowledge regarding fungal biology and pathogenesis, with an emphasis on adaptive mechanisms to tackle adverse conditions from host counteractions. This review outlines the current knowledge about dermatophyte infections, with a focus on signaling pathways required for fungal infection establishment and a broad perspective on cellular and molecular factors involved in antifungal resistance and tolerance. |
Databáze: | OpenAIRE |
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