Behavioral and Electroencephalographic Studies of Beagles with an Eck's Fistula: Suitability as a Model of Hepatic Encephalopathy
| Autor: | Sayo Itoh, Masayoshi Watanabe, Kazumasa Yamaguchi, Atsuya Matsumoto, Kiyoshi Kimura, Kohei Kyuki, Masami Katoh, Takeshi Mushiroi, Emi Kotani, Takayuki Ozaki, Yojiro Ukai, Fusao Ueda |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Flumazenil
Fistula Clinical Biochemistry Encephalopathy Drug Evaluation Preclinical Portacaval shunt Electroencephalography Toxicology Biochemistry GABA Antagonists Behavioral Neuroscience Dogs Ammonia Cortex (anatomy) medicine Animals Thyrotropin-Releasing Hormone Hepatic encephalopathy Biological Psychiatry Pharmacology Coma Behavior Animal medicine.diagnostic_test Portacaval Shunt Surgical business.industry Hyperammonemia medicine.disease Disease Models Animal Carbamazepine medicine.anatomical_structure Hepatic Encephalopathy Anesthesia Evoked Potentials Visual Anticonvulsants Central Nervous System Stimulants medicine.symptom business |
| Zdroj: | Pharmacology Biochemistry and Behavior. 57:367-375 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(96)00305-x |
| Popis: | Behavioral manifestations, electroencephalograms (EEGs) and visually evoked potentials (VEPs) were studied in beagles with Eck's fistula (portacaval shunt [PCS]), an established model of hyperammonemia, to determine whether they developed CNS disorders characteristic of hepatic encephalopathy. After PCS, behavioral changes occurred in the form of listlessness, sluggishness (altered gait, snapping and transient catatonia-like symptoms) and apparent blindness, which appeared in that order and progressed to coma and death in some animals. The EEGs from the frontal cortex showed a gradual decrease in voltage and frequency. Development of snapping and catatonia-like symptoms coincided with the occurrence of high voltage fast waves in the EEGs from the occipital cortex. In comatose Eck's fistula dogs, flattening of the EEGs was recorded from the frontal cortex and a lowered voltage was noted in the EEGs from the occipital cortex. After PCS, the latencies and amplitudes of the components of VEP were increased. The snapping and catatonia-like symptoms were markedly ameliorated by carbamazepine and the coma by flumazenil and thyrotropin-releasing hormone. These findings indicate that Eck's fistula dogs provide a useful model of hepatic encephalopathy. |
| Databáze: | OpenAIRE |
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