The metabolic pathways and transporters of the plastid organelle in Apicomplexa
| Autor: | Clément Em Lacour, Dominique Soldati-Favre, Joachim Kloehn |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Plasmodium Apicoplasts Microbiology Apicomplexa 03 medical and health sciences 0302 clinical medicine parasitic diseases Organelle Animals Parasites Plastid 030304 developmental biology 0303 health sciences Apicoplast biology Transporter biology.organism_classification 3. Good health Cell biology Metabolic pathway Infectious Diseases Toxoplasma Metabolic Networks and Pathways 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Microbiology. 63:250-258 |
| ISSN: | 1369-5274 |
| DOI: | 10.1016/j.mib.2021.07.016 |
| Popis: | The apicoplast is the relict of a plastid organelle found in several disease-causing apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii. In these organisms, the organelle has lost its photosynthetic capability but harbours several fitness-conferring or essential metabolic pathways. Although maintaining the apicoplast and fuelling the metabolic pathways within requires the challenging constant import and export of numerous metabolites across its four membranes, only few apicoplast transporters have been identified to date, most of which are orphan transporters. Here we review the roles of metabolic pathways within the apicoplast and what is currently known about the few identified apicoplast metabolite transporters. We discuss what metabolites must get in and out of the apicoplast, the many transporters that are yet to be discovered, and what role these might play in parasite metabolism and as putative drug targets. |
| Databáze: | OpenAIRE |
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