Investigation into the Pathology of Idiopathic Systemic Amyloidosis in Four Captive Badgers (Meles meles)
| Autor: | John Spiropoulos, Tobias Floyd, A. Godinho, Ute Weyer, A. Núñez, Ranieri Verin, David J. Everest, Sandrine Lesellier, Pedro J. Sánchez-Cordón, C. Bianco |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Pathology medicine.medical_specialty Amyloid Badger 040301 veterinary sciences Spleen Meles 030308 mycology & parasitology Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences biology.animal Mustelidae medicine Animals badger 0303 health sciences Mycobacterium bovis General Veterinary biology business.industry Amyloidosis amyloidosis histopathology pathology 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 3. Good health medicine.anatomical_structure Female Histopathology business Kidney disease |
| Zdroj: | Journal of Comparative Pathology |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/j.jcpa.2020.02.012 |
| Popis: | Systemic idiopathic amyloidosis was described in four captive badgers (Meles meles). Two animals (B1 and B2) were not enrolled in any trial, while animals B3 and B4 took part in a vaccine efficacy study and had been challenged with Mycobacterium bovis. A full set of tissues was collected and processed routinely for histopathological, immunohistochemical and ultrastructural studies. Splenomegaly was found in three out of four animals. Histopathological evaluation revealed congophilic, permanganate-resistant systemic amyloid deposits in the tissues of all badgers. Animals B2 and B4 displayed a marked granulomatous response to amyloid within the spleen. Animals B1 and B2 also displayed clinicopathological findings suggestive of chronic kidney disease. Ultrastructural examination identified peculiar star-shaped arrays of amyloid. Immunohistochemical studies were unrewarding. Systemic amyloidosis should be considered among the differentials of wasting in captive badgers. |
| Databáze: | OpenAIRE |
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