Correlation of immunohistochemical molecular staging of bladder biopsies and radical cystectomy specimens
| Autor: | William F. Benedict, Seth P. Lerner, Hideo Tokunaga, Aaran Green, Jain Hua Zhou, Shahrokh F. Shariat, Richard Brown |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Biopsy medicine.medical_treatment Urinary Bladder Urology Cystectomy Retinoblastoma Protein medicine Humans Radiology Nuclear Medicine and imaging In patient Cyclin-Dependent Kinase Inhibitor p16 Survival analysis Aged Proportional Hazards Models Aged 80 and over Analysis of Variance Carcinoma Transitional Cell Radiation Bladder cancer Urinary bladder medicine.diagnostic_test business.industry Organothiophosphorus Compounds Middle Aged Prognosis medicine.disease Neoplasm Proteins medicine.anatomical_structure Urinary Bladder Neoplasms Oncology Bladder Biopsy Disease Progression Immunohistochemistry Tumor Suppressor Protein p53 business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 51:16-22 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(01)01586-3 |
| Popis: | To determine the relationship of p53, retinoblastoma (RB), and p16 expression between precystectomy transurethral resection bladder (TURB) biopsy and matched cystectomy specimens; and to determine the value of p53 immunoreactivity for predicting progression and survival in patients undergoing radical cystectomy.We performed p53 immunohistochemical staining on matched archival TURB and cystectomy specimens taken from 40 patients. Twenty-seven and 26 of these patients were also evaluated for RB and p16 expression, respectively.Twenty-eight (70%) of the TURB and 22 (55%) of the cystectomy specimens stained positive for p53. RB and p16 protein expression were altered in 19 (70%) and 19 (73%) of the TURB specimens, respectively, and 19 (70%) and 19 (73%) of the cystectomy specimens, respectively. There was a strong correlation between p53, RB, and p16 expression and TURB and cystectomy specimens (all p0.001). In preoperative and postoperative multivariate analyses, biopsy p53 and cystectomy p53 were independently associated with disease progression (p = 0.049 and p = 0.034, respectively) and bladder cancer-related death (p = 0.044 and p = 0.037, respectively).p53, RB, and p16 expression patterns on TURB specimens correlate with cystectomy specimens. p53 immunoreactivity is an independent predictor of disease progression and bladder cancer survival. These data support the potential of prognostic staging using immunohistochemical analysis on bladder biopsy specimens prior to neoadjuvant or definitive therapy. |
| Databáze: | OpenAIRE |
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