The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development
| Autor: | Vincent Rucchin, Gauhar Masgutova, Karolina U. Kabayiza, Frédéric Clotman, Audrey Harris, Benvenuto Jacob |
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| Přispěvatelé: | UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Interneuron neural differentiation Population Sensory system Biology lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience transcription factors medicine onecut education Transcription factor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Molecular Biology Original Research education.field_of_study neuronal migration Embryogenesis spinal cord Spinal cord dorsal interneurons 030104 developmental biology medicine.anatomical_structure nervous system GDF7 embryonic development Neuroscience Onecut Transcription Factors |
| Zdroj: | Frontiers in Molecular Neuroscience Frontiers in Molecular Neuroscience, Vol. 10, no.n/A, p. n/A (2017) Frontiers in Molecular Neuroscience, Vol 10 (2017) |
| ISSN: | 1662-5099 |
| Popis: | During embryonic development, the dorsal spinal cord generates numerous interneuron populations eventually involved in motor circuits or in sensory networks that integrate and transmit sensory inputs from the periphery. The molecular mechanisms that regulate the specification of these multiple dorsal neuronal populations have been extensively characterized. In contrast, the factors that contribute to their diversification into smaller specialized subsets and those that control the specific distribution of each population in the developing spinal cord remain unknown. Here, we demonstrate that the Onecut transcription factors, namely Hepatocyte Nuclear Factor-6 (HNF-6) (or OC-1), OC-2 and OC-3, regulate the diversification and the distribution of spinal dorsal interneuron (dINs). Onecut proteins are dynamically and differentially distributed in spinal dINs during differentiation and migration. Analyzes of mutant embryos devoid of Onecut factors in the developing spinal cord evidenced a requirement in Onecut proteins for proper production of a specific subset of dI5 interneurons. In addition, the distribution of dI3, dI5 and dI6 interneuron populations was altered. Hence, Onecut transcription factors control genetic programs that contribute to the regulation of spinal dIN diversification and distribution during embryonic development. |
| Databáze: | OpenAIRE |
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