Transglutaminase type 2 in the regulation of proteostasis
| Autor: | Federica Rossin, Maria Grazia Farrace, Manuela D’Eletto, Olga Fedorova, Mauro Piacentini |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell physiology autophagy Settore BIO/06 Tissue transglutaminase Clinical Biochemistry exosomes Protein aggregation Biochemistry 03 medical and health sciences heat shock proteins mitophagy protein aggregates 0302 clinical medicine GTP-Binding Proteins Stress Physiological Heat shock protein Mitophagy Animals Humans Disease Protein Glutamine gamma Glutamyltransferase 2 Molecular Biology Transglutaminases biology Autophagy Cell biology 030104 developmental biology Proteostasis 030220 oncology & carcinogenesis biology.protein Intracellular Molecular Chaperones |
| Popis: | The maintenance of protein homeostasis (proteostasis) is a fundamental aspect of cell physiology that is essential for the survival of organisms under a variety of environmental and/or intracellular stress conditions. Acute and/or persistent stress exceeding the capacity of the intracellular homeostatic systems results in protein aggregation and/or damaged organelles that leads to pathological cellular states often resulting in cell death. These events are continuously suppressed by a complex macromolecular machinery that uses different intracellular pathways to maintain the proteome integrity in the various subcellular compartments ensuring a healthy cellular life span. Recent findings have highlighted the role of the multifunctional enzyme type 2 transglutaminase (TG2) as a key player in the regulation of intracellular pathways, such as autophagy/mitophagy, exosomes formation and chaperones function, which form the basis of proteostasis regulation under conditions of cellular stress. Here, we review the role of TG2 in these stress response pathways and how its various enzymatic activities might contributes to the proteostasis control. |
| Databáze: | OpenAIRE |
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