Childhood adversity and cortical thickness and surface area in a population at familial high risk of schizophrenia
| Autor: | Heather C. Whalley, Eve C. Johnstone, Andrew M. McIntosh, David G. C. Owens, Catherine Bois, Victoria Barker, Stephen M. Lawrie |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Adolescent Population Audiology Young Adult 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted Humans Medicine Genetic Predisposition to Disease Cortical surface Gray Matter education Applied Psychology Cerebral Cortex education.field_of_study business.industry Organ Size medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Adult Survivors of Child Adverse Events Schizophrenia Female business 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine. 46:891-896 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundThere is now a well-established link between childhood adversity (CA) and schizophrenia. Similar structural abnormalities to those found in schizophrenia including alterations in grey-matter volume have also been shown in those who experience CA.MethodWe examined whether global estimates of cortical thickness or surface area were altered in those familial high-risk subjects who had been referred to a social worker or the Children's Panel compared to those who had not.ResultsWe found that the cortical surface area of those who were referred to the Children's Panel was significantly smaller than those who had not been referred, but cortical thickness was not significantly altered. There was also an effect of social work referral on cortical surface area but not on thickness.ConclusionsCortical surface area increases post-natally more than cortical thickness. Our findings suggest that CA can influence structural changes in the brain and it is likely to have a greater impact on cortical surface area than on cortical thickness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|