Delta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia
| Autor: | Angella Bryan, Nicola R. K. Anders, Stuart Dolling, Brian J. Pollard, David G. Glover, Chris J. D. Pomfrett |
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| Rok vydání: | 2009 |
| Předmět: |
Dose-Response Relationship
Drug Isoflurane medicine.diagnostic_test medicine.drug_class business.industry Electroencephalography Hypnotic Anesthesiology and Pain Medicine Delta Sleep-Inducing Peptide Heart Rate Anesthesia Bispectral index Anesthetics Inhalation Delta Rhythm medicine Humans Heart rate variability Delta sleep-inducing peptide Female Propofol business medicine.drug |
| Zdroj: | European Journal of Anaesthesiology. 26:128-134 |
| ISSN: | 0265-0215 |
| DOI: | 10.1097/eja.0b013e32831c8644 |
| Popis: | Background & objectiveDelta sleep-inducing peptide (DSIP) is an endogenous peptide that crosses the blood brain barrier, named after its association with natural sleep and enhanced EEG delta rhythm. The objective of this study was to determine whether DSIP could be used as an adjunct to volatile anaesthesia in human subjects, our hypothesis being that DSIP is a natural hypnotic that would increase anaesthetic depth. The aims were to assess depth of anaesthesia using BIS, the EEG and heart rate variability, and to determine whether DSIP altered the symmetry of EEG between the left and right cerebral hemispheres.Methods24 female American Society of Anesthesiologists (ASA) score I or II patients gave written, informed consent to a protocol approved by our local research ethics committee. 12 were randomly assigned as controls to receive saline. 12 were randomly allocated to receive one of three intravenous bolus doses of DSIP (Clinalfa) at 25, 50 or 100 nM kg-1. The first administration of DSIP was while awake, the second after induction of anaesthesia with propofol and maintainance with isoflurane. BIS and EEG parameters were measured continuously using a bilateral electrode montage.ResultsDSIP significantly increased heart rate, decreased heart rate variability and paradoxically, significantly reduced delta rhythm along with reducing burst supression and increasing BIS at 25nM kg-1 during isoflurane anaesthesia. DSIP also significantly altered bilateral symmetry of the EEG.ConclusionDSIP probably reduced parasympathetic tone and decreased (lightened) the depth of anaesthesia measured using BIS. |
| Databáze: | OpenAIRE |
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