Kilovoltage rotational radiotherapy of breast cancer with the BriXS source
| Autor: | Vittoria Petrillo, A. Bacci, Angelo Taibi, Simone Cialdi, Antonio Sarno, Gianfranco Paternò, I. Drebot, Paolo Russo, P. Cardarelli, Giovanni Mettivier, Luca Serafini |
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| Přispěvatelé: | Sarno, A., Mettivier, G., Russo, P., Drebot, I., Petrillo, V., Bacci, A., Cialdi, S., Cardarelli, P., Paterno, G., Taibi, A., Serafini, L. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Accelerator Applications
Quantitative Biology::Tissues and Organs medicine.medical_treatment Physics::Medical Physics Monte Carlo method Socio-culturale Breast radiotherapy Radiotherapy concept 01 natural sciences X-ray generators and sources Linear particle accelerator 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer 0103 physical sciences medicine Cylinder Instrumentation Mathematical Physics Physics 010308 nuclear & particles physics business.industry Synchrotron Radiation Source medicine.disease Radiotherapy concepts Radiation therapy Accelerator Application Instrumentation for gamma-electron therapy Rotational axis Nuclear medicine business |
| Popis: | Kilovoltage rotational radiotherapy of breast cancer has been proposed as an alternative procedure to the conventional breast radiotherapy with 6 MeV photon beams. The use of orthovoltage X-ray tubes rotating around the breast, instead of conventional medical linear accelerators, would allow for significant reduction of acquisition and management costs. However, the employment of an X-ray tube limits the maximum available photon flux: a synchrotron radiation source could provide a high dose rate, but its clinical use is prevented by the size of such a source. In this work, we propose the use of the BriXS twin Compton pulsed X-ray source as a compact alternative to the synchrotron radiation source, for kilovoltage radiotherapy of breast cancer. This proposed source presents a footprint of 40 m × 20 m, and the X-ray spectrum presents a mean energy of 88 keV with a suitable photon flux. The dose distribution in a simulated radiotherapy session was computed via a Monte Carlo software based on the Geant4 simulation toolkit. The study focused on the skin dose ratio, i.e. the percent ratio between the dose to the skin and that to the tumor volume in the modelled breast. A low skin dose allows for a suitable sparing of skin tissue during radiotherapy. For a cylindrical model breast with a diameter of 140 mm embedding a spherical simulated lesion with a diameter of 10 mm placed at the rotational axis of the cylinder, the calculated skin-to-tumor dose ratio was as low as 7%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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