Effects of ionic and non-ionic paramagnetic contrast media on brain bio-electric activity
| Autor: | Gabriele Polonara, Leandro Provinciali, Anna Messori, U. Salvolini, M. Signorino, L. Regnicolo |
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| Rok vydání: | 2004 |
| Předmět: |
Gadolinium DTPA
medicine.medical_specialty Neurology Gadolinium Central nervous system chemistry.chemical_element Contrast Media Electroencephalography Statistics Nonparametric Nuclear magnetic resonance Double-Blind Method medicine Humans Radiology Nuclear Medicine and imaging Analysis of Variance medicine.diagnostic_test business.industry Brain Neoplasms Gadodiamide Brain Magnetic resonance imaging Magnetic Resonance Imaging Contrast medium Electrophysiology medicine.anatomical_structure chemistry Blood-Brain Barrier Injections Intravenous Neurology (clinical) Cardiology and Cardiovascular Medicine Nuclear medicine business medicine.drug |
| Zdroj: | Neuroradiology. 47(11) |
| ISSN: | 0028-3940 |
| Popis: | The potential neurotoxic effects of gadolinium (Gd)-based compounds for enhanced MRI are not completely understood. We investigated electroencephalography changes induced by ionic and non-ionic Gd-based compounds administered intravenously in patients affected by lesions of the central nervous system (CNS) characterized by breakdown of the blood-brain barrier. This double-blind, randomized, study of two parallel groups involved 40 patients scheduled for an MRI examination with contrast medium for known CNS lesions. Twenty patients were randomly allocated to receive non-ionic Gd-DTPA-BMA/gadodiamide and 20 patients were randomly allocated to receive ionic Gd-DTPA/gadopentetate. For both groups the intravenous dose was 0.1 mmol/kg body weight. Three electroencephalography recordings were performed: immediately before, during, and 15 min after contrast medium injection. Mean and peak frequencies of the beta band and absolute power of the delta and/or theta bands of the electroencephalograms (EEGs) were noted. Each EEG was also evaluated to detect any alterations. The values of the 8-12 Hz band showed a significant increase during and after injection versus baseline in the gadopentetate group (P |
| Databáze: | OpenAIRE |
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