Better Understanding the Disparity Associated With Black Race in Heart Transplant Outcomes: A National Registry Analysis
| Autor: | Mary G. Bowring, Robert S.D. Higgins, Dorry L. Segev, Hasina Maredia, Shakirat Oyetunji, Sunjae Bae, Amber B. Kernodle, Christian A. Merlo, Allan B. Massie, Errol L. Bush |
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| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
Male Kaplan-Meier Estimate 030204 cardiovascular system & hematology 030230 surgery 0302 clinical medicine Cause of Death Epidemiology Risk of mortality Registries Aged 80 and over Age Factors Hispanic or Latino Middle Aged Histocompatibility Educational Status Female Cardiology and Cardiovascular Medicine Cardiomyopathies Immunosuppressive Agents Adult Heart Defects Congenital medicine.medical_specialty Adolescent Black race Article Tacrolimus White People 03 medical and health sciences Young Adult Sex Factors medicine Diabetes Mellitus Humans Healthcare Disparities Mortality Glucocorticoids American Indian or Alaska Native Aged Antilymphocyte Serum Proportional Hazards Models Heart Failure White (horse) Insurance Health business.industry Mycophenolic Acid Black or African American Heart Transplantation Interleukin-2 National registry business Demography |
| Zdroj: | Circ Heart Fail |
| ISSN: | 1941-3297 |
| Popis: | Background: Black heart transplant recipients have higher risk of mortality than White recipients. Better understanding of this disparity, including subgroups most affected and timing of the highest risk, is necessary to improve care of Black recipients. We hypothesize that this disparity may be most pronounced among young recipients, as barriers to care like socioeconomic factors may be particularly salient in a younger population and lead to higher early risk of mortality. Methods: We studied 22 997 adult heart transplant recipients using the Scientific Registry of Transplant Recipients data from January 2005 to 2017 using Cox regression models adjusted for recipient, donor, and transplant characteristics. Results: Among recipients aged 18 to 30 years, Black recipients had 2.05-fold (95% CI, 1.67–2.51) higher risk of mortality compared with non-Black recipients ( P P P P =0.4). This association was attenuated among recipients aged 31 to 40 and 41 to 60 years, in whom Black recipients had 1.53-fold ([95% CI, 1.25–1.89] P P P =0.1). Conclusions: Young Black recipients have a high risk of mortality in the first year after heart transplant, which has been masked in decades of research looking at disparities in aggregate. To reduce overall racial disparities, clinical research moving forward should focus on targeted interventions for young Black recipients during this period. |
| Databáze: | OpenAIRE |
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