Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice
Autor: | Elizabeth Simpson, SJ Rose, MA Maibaum, Michelle E. K. Haywood, MB Hogarth, Kevin A. Davies, Phillip Chandler, PJ Allen, Mark Walport, JH Slingsby, Bernard J Morley, EM Thompson |
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Rok vydání: | 2000 |
Předmět: |
Male
Genetic Linkage Immunology Mice Inbred Strains Biology Quantitative trait locus Chromosomes Mice Rheumatology immune system diseases Genetic linkage medicine Immunology and Allergy Animals Humans Lupus Erythematosus Systemic Pharmacology (medical) Genetic Predisposition to Disease Allele skin and connective tissue diseases Alleles Chromosome 13 Genetics Lupus erythematosus Systemic lupus erythematosus Chromosomes Human Pair 13 Chromosome DNA medicine.disease Chromosome 3 Chromosomes Human Pair 1 Antibodies Antinuclear Chromosomes Human Pair 3 |
Zdroj: | Arthritis and rheumatism. 43(2) |
ISSN: | 0004-3591 |
Popis: | Objective To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice. Methods We analyzed 286 (B10 × [B10 × BXSB]F1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and quantitative trait locus analysis. Results The disease phenotype in these backcross mice was less severe than that in BXSB mice. However, antinuclear antibody production was increased compared with the parental strain. We identified 4 areas of genetic linkage to disease on chromosome 1 (Bxs1–4), 1 on chromosome 3 (Bxs5), and another interval on chromosome 13 which were associated with various aspects of the phenotype. Bxs4 and Bxs5 are located in regions not previously linked to disease in other models of SLE. Conclusion SLE in the BXSB mouse model has a complex genetic basis and involves at least 5 distinct intervals located on chromosomes 1 and 3. There is evidence that different intervals affect particular aspects of the SLE phenotype. |
Databáze: | OpenAIRE |
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