New perspective to develop memantine orally disintegrating tablet formulations: SeDeM expert system
| Autor: | Nevin Celebi, Alptug Karakucuk, Sıla Gülbağ, Hazal Ezgi Gültekin, Ayse Nur Oktay, Duygu Yilmaz Usta, Özden Demirtaş |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Orally disintegrating tablet
Computer science Drug Compounding Pharmaceutical Science Expert Systems 02 engineering and technology Pharmacology Friability computer.software_genre 030226 pharmacology & pharmacy Quality by Design Antiparkinson Agents Excipients 03 medical and health sciences 0302 clinical medicine Hardness Memantine medicine Process engineering Drug compounding business.industry General Medicine 021001 nanoscience & nanotechnology Expert system Drug Liberation Solubility 0210 nano-technology business computer Tablets medicine.drug |
| Popis: | Nowadays pharmaceutical industries and regulatory authorities suggest new approaches such as Quality by Design principles to reduce experiments of formulation studies, improve product quality, save cost and time. SeDeM Expert System is a predictive approach for the preformulation studies and it provides information about suitability of API for direct compression by evaluating 12 parameters. The system also allows selecting appropriate excipients by determining same parameters to improve compressibility of API. The objective of this study was to develop direct compressed memantine orally disintegrating tablets using SeDeM Expert System. Memantine was found to have poor flow and compressibility properties. Three different direct compressibility and super disintegrating agents (Ludiflash((R)), Ludipress((R)) and Parteck((R))) were used to improve compressibility of memantine and according to SeDeM diagrams, Parteck((R)) was selected for final formulation. Memantine direct compressed tablets showed proper friability, hardness and thickness. The disintegration time of the tables were found below 15s which was suitable for ODTs. It was found that SeDeM Expert System was easy to use and application of this method provided to develop memantine direct compressed ODT formulation was successful. |
| Databáze: | OpenAIRE |
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