Naloxone reverses the serotonin dependent hypotensive action of CGP 6085 A
| Autor: | Harry R. Keiser, Elliott C. Kulakowski, Daniel J. Goldstein, Phyllis Brown, Thomas G. Ropchak |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
medicine.medical_specialty Serotonin Serotonin uptake Methysergide Blood Pressure (+)-Naloxone Hypotensive action General Biochemistry Genetics and Molecular Biology Piperidines Internal medicine Medicine Animals General Pharmacology Toxicology and Pharmaceutics Antihypertensive Agents business.industry Naloxone Antagonist Fenclonine General Medicine Rats Endocrinology Blood pressure Arterial blood sense organs Serotonin Antagonists business medicine.drug |
| Zdroj: | Life sciences. 41(11) |
| ISSN: | 0024-3205 |
| Popis: | CGP 6085 A, a specific 5-hydroxytryptamine (5-HT), serotonin uptake inhibitor, is also a potent hypotensive agent. Its depressor effect in the spontaneously hypertensive (SH) rats correlates well with its ability to inhibit serotonin uptake. Here we report that the effects of CGP 6085 A on arterial blood pressure were greatly reduced in rats pretreated with p-chlorophenylalanine (pCl-Phe), a specific depletor of serotonin. Moreover, in rats pretreated with the serotonin antagonist, methysergide, CGP 6085 A did not produce significant hypotension. We also found that centrally administered naloxone reverses the hypotensive effect of CGP 6085 A. These results provide further evidence for the existence of an important serotonin-opioid interaction in the mechanisms of arterial blood regulation in the rat. |
| Databáze: | OpenAIRE |
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